thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin

Stable Identifier
R-HSA-140870
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
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Summation

Antithrombin III in the complex is cleaved by thrombin, thereupon undergoing a conformational change that stabilizes the thrombin:antithrombin III complex, trapping and inactivating the thrombin moiety.

Literature References
PubMed ID Title Journal Year
12907439 Heparin-induced substrate behavior of antithrombin Cambridge II Blood 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of thrombin:antithrombin III:heparin [plasma membrane]
Physical Entity
thrombin:antithrombin III:heparin [plasma membrane]
Activity
serine-type endopeptidase activity (0004252)
Orthologous Events
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Bos taurus)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Canis familiaris)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Danio rerio)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Gallus gallus)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Mus musculus)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Rattus norvegicus)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Sus scrofa)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Taeniopygia guttata)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Xenopus tropicalis)