Reactome: A Curated Pathway Database

thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (R-HSA-140870) [Homo sapiens]

Reaction
Summation

Antithrombin III in the complex is cleaved by thrombin, thereupon undergoing a conformational change that stabilizes the thrombin:antithrombin III complex, trapping and inactivating the thrombin moiety.

Additional Information
Compartment plasma membrane
Literature References
pubMedId Title Journal Year
12907439 Heparin-induced substrate behavior of antithrombin Cambridge II Blood 2003