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thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin

Stable Identifier
R-HSA-140870
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Antithrombin III in the complex is cleaved by thrombin, thereupon undergoing a conformational change that stabilizes the thrombin:antithrombin III complex, trapping and inactivating the thrombin moiety.

Literature References
PubMed ID Title Journal Year
12907439 Heparin-induced substrate behavior of antithrombin Cambridge II Blood 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of thrombin:antithrombin III:heparin [plasma membrane]
Physical Entity
Activity
Orthologous Events