Reactome: A Curated Pathway Database

thrombin:cleaved antithrombin III:heparin -> thrombin:cleaved antithrombin III + heparin (R-HSA-140872)

Species Homo sapiens


The same conformational change that traps thrombin in its complex with cleaved antithrombin III also decreases the affinity of the latter for heparin, and the complex of cleaved antithrombin III and thrombin dissociates from the cell-bound heparin molecule.

Locations in the PathwayBrowser
Additional Information
Compartment extracellular region , plasma membrane
Literature References
pubMedId Title Journal Year
12907439 Heparin-induced substrate behavior of antithrombin Cambridge II Blood 2003