thrombin:cleaved antithrombin III:heparin -> thrombin:cleaved antithrombin III + heparin

Stable Identifier
R-HSA-140872
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The same conformational change that traps thrombin in its complex with cleaved antithrombin III also decreases the affinity of the latter for heparin, and the complex of cleaved antithrombin III and thrombin dissociates from the cell-bound heparin molecule.

Literature References
PubMed ID Title Journal Year
12907439 Heparin-induced substrate behavior of antithrombin Cambridge II Blood 2003
Participants
Participant Of
Orthologous Events