Reactome: A Curated Pathway Database
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The citric acid (TCA) cycle and respiratory electron transport

Stable Identifier
R-HSA-1428517
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalents are re-oxidized back to NAD+ in the electron transport chain (ETC), coupling this process with the export of protons across the inner mitochondrial membrane. The chemiosmotic gradient created is used to drive ATP synthesis.

Participants
Participant Of
hasEvent
Orthologous Events