Reactome: A Curated Pathway Database

AKT1,AKT2 phosphorylates AS160 (TBC1D4)

Stable Identifier
R-HSA-1445144
Type
Reaction
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane, cytosol
Locations in the PathwayBrowser
Summation

As inferred from mouse, AKT2 and, to a lesser extent, AKT1 phosphorylate AS160 (TBC1D4) in response to insulin signaling (Howlett et al. 2007, Karlsson et al 2005). AS160, a RAB GTPase activating protein, interacts with IRAP (LNPEP) and is associated with cytoplasmic vesicles containing GLUT4 (SLC2A4).

Literature References
PubMed ID Title Journal Year
15919790 Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects Diabetes 2005
17369524 Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle Diabetes 2007
Participants
input
output
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of p-T308,S473-AKT1 [plasma membrane] p-T308,S473-AKT1 [plasma membrane] protein serine/threonine kinase activity (0004674)
protein serine/threonine kinase activity of p-T309,S474-AKT2 [plasma membrane] p-T309,S474-AKT2 [plasma membrane] protein serine/threonine kinase activity (0004674)
Inferred From
 
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