Reactome: A Curated Pathway Database
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AKT1,AKT2 phosphorylates AS160 (TBC1D4)

Stable Identifier
R-HSA-1445144
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

As inferred from mouse, AKT2 and, to a lesser extent, AKT1 phosphorylate AS160 (TBC1D4) in response to insulin signaling (Howlett et al. 2007, Karlsson et al 2005). AS160, a RAB GTPase activating protein, interacts with IRAP (LNPEP) and is associated with cytoplasmic vesicles containing GLUT4 (SLC2A4).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of p-T308,S473-AKT1 [plasma membrane] p-T308,S473-AKT1 [plasma membrane] protein serine/threonine kinase activity (0004674)
protein serine/threonine kinase activity of p-T309,S474-AKT2 [plasma membrane] p-T309,S474-AKT2 [plasma membrane] protein serine/threonine kinase activity (0004674)
Inferred From