Reactome: A Curated Pathway Database

p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)

Stable Identifier
R-HSA-1445144
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol, cytoplasmic vesicle membrane
Locations in the PathwayBrowser
Summation

As inferred from mouse, AKT2 and, to a lesser extent, AKT1 phosphorylate AS160 (TBC1D4) in response to insulin signaling (Howlett et al. 2007, Karlsson et al 2005). AS160, a RAB GTPase activating protein, interacts with IRAP (LNPEP) and is associated with cytoplasmic vesicles containing GLUT4 (SLC2A4).

Literature References
PubMed ID Title Journal Year
17369524 Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle Diabetes 2007
15919790 Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects Diabetes 2005
Participants
input
output
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of p-T309,S474-AKT2 [plasma membrane] p-T309,S474-AKT2 [plasma membrane] protein serine/threonine kinase activity (0004674)
protein serine/threonine kinase activity of p-T308,S473-AKT1 [plasma membrane] p-T308,S473-AKT1 [plasma membrane] protein serine/threonine kinase activity (0004674)
Inferred From
 
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