Reactome: A Curated Pathway Database

AKT1,AKT2 phosphorylates AS160 (TBC1D4) (R-HSA-1445144)

Species Homo sapiens

Summation

As inferred from mouse, AKT2 and, to a lesser extent, AKT1 phosphorylate AS160 (TBC1D4) in response to insulin signaling (Howlett et al. 2007, Karlsson et al 2005). AS160, a RAB GTPase activating protein, interacts with IRAP (LNPEP) and is associated with cytoplasmic vesicles containing GLUT4 (SLC2A4).

Locations in the PathwayBrowser
Additional Information
Compartment cytoplasmic vesicle membrane , cytosol