Reactome | p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)

p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)

Stable Identifier

R-HSA-1445144

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

cytosol, cytoplasmic vesicle membrane

Locations in the PathwayBrowser

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Summation

As inferred from mouse, AKT2 and, to a lesser extent, AKT1 phosphorylate AS160 (TBC1D4) in response to insulin signaling (Howlett et al. 2007, Karlsson et al 2005). AS160, a RAB GTPase activating protein, interacts with IRAP (LNPEP) and is associated with cytoplasmic vesicles containing GLUT4 (SLC2A4).

Literature References

PubMed ID	Title	Journal	Year
17369524	Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle	Diabetes	2007
15919790	Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects	Diabetes	2005

Participants

Input

Output

Participant Of

hasEvent

Translocation of SLC2A4 (GLUT4) to the plasma membrane

Catalyst Activity

Title

protein serine/threonine kinase activity of p-AKT1,p-AKT2 [plasma membrane]

Physical Entity

p-AKT1,p-AKT2 [plasma membrane]

Activity

protein serine/threonine kinase activity (0004674)

Inferred From

Akt Phosphorylates As160 (Tbc1d4) (Mus musculus)