Reactome: A Curated Pathway Database

Collagen type II degradation by MMP14

Stable Identifier
R-HSA-1474196
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The membrane-type MMP MMP14 (MT1-MMP) is a fibrillar collagenase. MMP14 is able to degrade collagen types I, II and III (Ohuchi et al. 1997).

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
serine-type endopeptidase activity of MMP14,TMPRSS6 [plasma membrane] MMP14,TMPRSS6 [plasma membrane] serine-type endopeptidase activity (0004252)
Inferred From