Reactome: A Curated Pathway Database

Collagen type II degradation by MMP1,3,8,13,PRSS2 (R-HSA-1474197) [Homo sapiens]


MMP1 (Welgus et al. 1981), MMP8 (Hasty et al. 1987), and MMP13 (Knauper et al. 1996, Mitchell et al. 1996, Billinghurst et al. 1997) known in the literature as collagenases I, II and III respectively are able to digest the intrahelical bonds of collagen type II, cleaving between amino acids Gly975 and Leu976 of the Uniprot canonical sequence. Human trypsin-2 is also capable of cleaving the triple helix of human cartilage collagen type II (Stenman et al. 2005).

Additional Information
Compartment extracellular region
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Input entries
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Catalyst Activity
PhysicalEntity Activity Active Units
MMP1,3,8,13, PRSS2 serine-type endopeptidase activity (0004252)