Reactome: A Curated Pathway Database

Collagen type II degradation by MMP1,3,8,13,PRSS2

Stable Identifier
R-HSA-1474197
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MMP1 (Welgus et al. 1981), MMP8 (Hasty et al. 1987), and MMP13 (Knauper et al. 1996, Mitchell et al. 1996, Billinghurst et al. 1997) known in the literature as collagenases I, II and III respectively are able to digest the intrahelical bonds of collagen type II, cleaving between amino acids Gly975 and Leu976 of the Uniprot canonical sequence. Human trypsin-2 is also capable of cleaving the triple helix of human cartilage collagen type II (Stenman et al. 2005).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
serine-type endopeptidase activity of MMP1,3,8,13, PRSS2 [extracellular region] MMP1,3,8,13, PRSS2 [extracellular region] serine-type endopeptidase activity (0004252)
Orthologous Events