Reactome | Acyl chain remodelling of PC

Acyl chain remodelling of PC

Stable Identifier

R-HSA-1482788

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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In the acyl chain remodelling pathway (Lands cycle), phosphatidylcholine (PC) is hydrolysed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid composition of glycerophospholipids to generate diverse molecules asymmetrically distributed in the cell membrane (Ghomashchi et al. 2010, Singer et al. 2002, Cao et al. 2008, Zhao et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
20705608	Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms Lehr, M, Gelb, MH, Aloulou, A, Naika, GS, Bollinger, JG, Ghomashchi, F, Leslie, CC	J Biol Chem	2010
18195019	Identification and characterization of a major liver lysophosphatidylcholine acyltransferase Bensch, WR, Li, S, Cao, G, Bonacci, TM, Moller, DE, Bredt, DS, Kowala, M, Chen, YQ, Zhao, Y, Konrad, RJ	J Biol Chem	2008
18458083	Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 Revett, T, Tobin, JF, Cao, J, Li, D, Shan, D, Gimeno, RE, Wu, L, Liu, W	J Biol Chem	2008
12359733	Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 Gelb, MH, Le Calvez, C, Ghomashchi, F, Rouault, M, Singer, AG, Sadilek, M, Bollinger, J, Bezzine, S, Lambeau, G, Lazdunski, M, Nguyen, E	J Biol Chem	2002