Acyl chain remodelling of PE (R-HSA-1482839) [Homo sapiens]


In the acyl chain remodelling pathway (Lands cycle), phosphatidylethanolamine (PE) is hydrolyzed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid composition of glycerophospholipids to generate diverse molecules asymmetrically distributed in the cell membrane (Ghomashchi et al. 2010, Singer et al. 2002, Cao et al. 2008, Zhao et al. 2008, Hishikawa et al. 2008).

Locations in the PathwayBrowser
Additional Information
GO Biological Process phosphatidylethanolamine acyl-chain remodeling (0036152)
Literature References
pubMedId Title Journal Year
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms J Biol Chem 2010
12359733 Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 J Biol Chem 2002
18458083 Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 J Biol Chem 2008
18195019 Identification and characterization of a major liver lysophosphatidylcholine acyltransferase J Biol Chem 2008
18287005 Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity Proc Natl Acad Sci U S A 2008
Inferred Entries
Orthologous events