Reactome: A Curated Pathway Database

Acyl chain remodelling of PG (R-HSA-1482925)

Species Homo sapiens


In the acyl chain remodelling pathway (Lands cycle), phosphatidylglycerol (PG) is hydrolyzed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid composition of glycerophospholipids to generate diverse molecules asymmetrically distributed in the cell membrane. The events occur additionally in the inner mitochondria membranes (IM) as well as in the endoplasmic reticulum (ER) membrane (Ghomashchi et al. 2010, Singer et al. 2002, Cao et al. 2008, Yang et al. 2004, Nie et al. 2010).

Locations in the PathwayBrowser
Additional Information
GO Biological Process phosphatidylglycerol acyl-chain remodeling (0036148)