Acyl chain remodelling of PG (R-HSA-1482925) [Homo sapiens]


In the acyl chain remodelling pathway (Lands cycle), phosphatidylglycerol (PG) is hydrolyzed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid composition of glycerophospholipids to generate diverse molecules asymmetrically distributed in the cell membrane. The events occur additionally in the inner mitochondria membranes (IM) as well as in the endoplasmic reticulum (ER) membrane (Ghomashchi et al. 2010, Singer et al. 2002, Cao et al. 2008, Yang et al. 2004, Nie et al. 2010).

Locations in the PathwayBrowser
Additional Information
GO Biological Process phosphatidylglycerol acyl-chain remodeling (0036148)
Literature References
pubMedId Title Journal Year
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms J Biol Chem 2010
12359733 Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 J Biol Chem 2002
18458083 Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 J Biol Chem 2008
15485873 Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase J Biol Chem 2004
20025994 A novel function of the human CLS1 in phosphatidylglycerol synthesis and remodeling Biochim Biophys Acta 2010
Inferred Entries
Orthologous events