Reactome: A Curated Pathway Database

Synthesis of PC

Stable Identifier
R-HSA-1483191
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

De novo (Kennedy pathway) synthesis of phosphatidylcholine (PC) involves phosphorylation of choline (Cho) to phosphocholine (PCho) followed by condensing with cytidine triphosphate (CTP) to form CDP-choline (CDP-Cho). Diacylglycerol (DAG) and CDP-ETA together then form PC. Alternatively, PC is formed when phosphatidylethanolamine (PE) is methylated by phosphatidylethanolamine N-methyltransferase (PEMT) (Henneberry et al. 2002; Wright & McMaster 2002).

Literature References
Participants
Participant Of
Orthologous Events