De novo (Kennedy pathway) synthesis of phosphatidylethanolamine (PE) involves phosphorylation of ethanolamine (ETA) to phosphoethanolamine (PETA) followed by condensing with cytidine triphosphate (CTP) to form CDP-ethanolamine (CDP-ETA). Diacylglycerol (DAG) and CDP-ETA together then form PE. Alternatively, PE is formed when phosphatidylserine (PS) is decarboxylated by phosphatidylserine decarboxylase proenzyme (PISD) (Henneberry et al. 2002, Vance 1991, Vance 1990).
|GO Biological Process||phosphatidylethanolamine biosynthetic process (0006646)|
|12221122||The major sites of cellular phospholipid synthesis and molecular determinants of Fatty Acid and lipid head group specificity||Mol Biol Cell||2002|
|1898727||Newly made phosphatidylserine and phosphatidylethanolamine are preferentially translocated between rat liver mitochondria and endoplasmic reticulum||J Biol Chem||1991|
|2332429||Phospholipid synthesis in a membrane fraction associated with mitochondria||J Biol Chem||1990|