ETA is phosphorylated to PETA by CHK/ETNK

Stable Identifier
R-HSA-1483222
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In the cytosol, ethanolamine (ETA) is phosphorylated to phosphoethanolamine (PETA) by choline kinase (CHK) dimer or by ethanolamine kinase 1/2 (ETNK1/2) (Lykidis et al. 2001, Gallego-Ortega et al. 2009). CHK dimer consists of either choline kinase alpha subunit (CHKA) or beta subunit (CHKB) homodimer, or of CHKA:CHKB heterodimer.

Literature References
PubMed ID Title Journal Year
19915674 Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment

Gallego-Ortega, D, Ramirez de Molina, A, Ramos, MA, Valdes-Mora, F, Barderas, MG, Sarmentero-Estrada, J, Lacal, JC

PLoS One 2009
11044454 Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway

Lykidis, A, Wang, J, Karim, MA, Jackowski, S

J Biol Chem 2001
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ethanolamine kinase activity of CHK/ETNK [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored