Reactome: A Curated Pathway Database

3' -UTR-mediated translational regulation (R-HSA-157279)

Species Homo sapiens


Translational control mechanisms often involve interactions between the 3' - or 5' -untranslated regions (UTRs) of mRNA and RNA-binding proteins. One such mechanism requires circularization of the mRNA molecule involving protein-protein interactions between the mRNA termini (Mazumder et al., 2001). While the circularization of mRNA during translation initiation is thought to contribute to an increase in the efficiency of translation, it also appears to provide a mechanism for translational silencing. This might be achieved by bringing inhibitory 3' UTR-binding proteins into a position in which they interfere either with the function of the translation initiation complex or with the assembly of the ribosome.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol
Literature References
pubMedId Title Journal Year
15459663 Molecular mechanisms of translational control Nat Rev Mol Cell Biol 2004
12575997 Translational control by the 3'-UTR: the ends specify the means Trends Biochem Sci 2003