Reactome: A Curated Pathway Database

NEXT2 is cleaved to produce NICD2

Stable Identifier
R-HSA-157640
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NEXT2 fragment of NOTCH2 is further cleaved at the S3 site by the gamma-secretase complex, which releases the intracellular domain NICD2 into the cytosol (Saxena et al. 2001, De Strooper et al. 1999, Schroeter et al. 1998, Fortini 2002).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane] gamma-secretase complex [plasma membrane] aspartic-type endopeptidase activity (0004190)
Inferred From