NEXT4 is cleaved to produce NICD4

Stable Identifier
R-HSA-157648
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NEXT4 fragment of NOTCH4 is further cleaved at the S3 site by the gamma-secretase complex, which relases the intracellular domain NICD4 into the cytosol.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
Physical Entity
Activity
Orthologous Events