Reactome: A Curated Pathway Database
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NEXT4 is cleaved to produce NICD4

Stable Identifier
R-HSA-157648
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NEXT4 fragment of NOTCH4 is further cleaved at the S3 site by the gamma-secretase complex, which relases the intracellular domain NICD4 into the cytosol.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane] gamma-secretase complex [plasma membrane] aspartic-type endopeptidase activity (0004190)
Orthologous Events