Reactome: A Curated Pathway Database

NEXT4 is cleaved to produce NICD4 (R-HSA-157648) [Homo sapiens]


NEXT4 fragment of NOTCH4 is further cleaved at the S3 site by the gamma-secretase complex, which relases the intracellular domain NICD4 into the cytosol.

Additional Information
Compartment cytosol , plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
gamma-secretase complex aspartic-type endopeptidase activity (0004190)