Reactome: A Curated Pathway Database

NEXT3 is cleaved to produce NICD3

Stable Identifier
R-HSA-157659
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NEXT3 fragment of NOTCH3 is further cleaved at the S3 site by the gamma-secretase complex, which relases the intracellular domain NICD3 into the cytosol.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane] gamma-secretase complex [plasma membrane] aspartic-type endopeptidase activity (0004190)
Orthologous Events