Reactome: A Curated Pathway Database

NEXT3 is cleaved to produce NICD3 (R-HSA-157659) [Homo sapiens]


NEXT3 fragment of NOTCH3 is further cleaved at the S3 site by the gamma-secretase complex, which relases the intracellular domain NICD3 into the cytosol.

Additional Information
Compartment cytosol , plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
gamma-secretase complex aspartic-type endopeptidase activity (0004190)