factor XIIa + C1Inh -> factor XIIa:C1Inh

Stable Identifier
R-HSA-158357
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activated factor XII (factor XIIa) binds to C1Inh (C1 inhibitor - Bock et al. 1986) to form a stable, inactive complex (Schneider et al. 1973). While several protease inhibitors can form stable complexes with XIIa in vitro, only C1Inh does so to a significant extent under normal conditions in vivo (Pixley et al. 1985).

Literature References
PubMed ID Title Journal Year
2578463 The regulation of human factor XIIa by plasma proteinase inhibitors

Pixley, RA, Schapira, M, Colman, RW

J Biol Chem 1985
3756141 Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization

Bock, SC, Skriver, K, Nielsen, E, Thogersen, HC, Wiman, B, Donaldson, VH, Eddy, RL, Marrinan, J, Radziejewska, E, Huber, R, Magnusson, S

Biochemistry 1986
4703226 Inhibition by C1INH of Hagemann factor fragment activation of coagulation, fibrinolysis, and kinin generation

Schreiber, AD, Kaplan, AP, Austen, KF

J Clin Invest 1973
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