Activated factor XII (factor XIIa) binds to C1Inh (C1 inhibitor - Bock et al. 1986) to form a stable, inactive complex (Schneider et al. 1973). While several protease inhibitors can form stable complexes with XIIa in vitro, only C1Inh does so to a significant extent under normal conditions in vivo (Pixley et al. 1985).
|3756141||Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization||Biochemistry||1986|
|2578463||The regulation of human factor XIIa by plasma proteinase inhibitors||J Biol Chem||1985|
|4703226||Inhibition by C1INH of Hagemann factor fragment activation of coagulation, fibrinolysis, and kinin generation||J Clin Invest||1973|