Reactome: A Curated Pathway Database

factor XIIa + C1Inh -> factor XIIa:C1Inh (R-HSA-158357) [Homo sapiens]


Activated factor XII (factor XIIa) binds to C1Inh (C1 inhibitor - Bock et al. 1986) to form a stable, inactive complex (Schneider et al. 1973). While several protease inhibitors can form stable complexes with XIIa in vitro, only C1Inh does so to a significant extent under normal conditions in vivo (Pixley et al. 1985).

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Compartment extracellular region
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