Reactome: A Curated Pathway Database
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factor XIIa + C1Inh -> factor XIIa:C1Inh

Stable Identifier
R-HSA-158357
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activated factor XII (factor XIIa) binds to C1Inh (C1 inhibitor - Bock et al. 1986) to form a stable, inactive complex (Schneider et al. 1973). While several protease inhibitors can form stable complexes with XIIa in vitro, only C1Inh does so to a significant extent under normal conditions in vivo (Pixley et al. 1985).

Literature References
Participants
Participant Of
Orthologous Events