Reactome: A Curated Pathway Database

kallikrein + C1Inh -> kallikrein:C1Inh (R-HSA-158399) [Homo sapiens]


Activated kallikrein binds to C1Inh (plasma protease C1 inhibitor) (Bock et al. 1986), forming a stable and enzymatically inactive complex. This reaction appears to be the major means by which kallikrein is inactivated (kallikrein can also be inactivated by binding to alpha2-macroglobulin) (Harpel et al. 1985; Ratnoff et al. 1969).

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Compartment extracellular region
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