Reactome: A Curated Pathway Database

Expression of ALAS1

Stable Identifier
R-HSA-1592238
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Expression of 5-aminolevulinate synthase 1
Locations in the PathwayBrowser
Summation

The ALAS1 gene is transcribed to yield mRNA and the mRNA is translated in the cytosol to yield precursor protein. The ALAS1 precursor is imported into the mitochodrial matrix where it catalyzes the synthesis of 5-aminolevulinate from glycine and succinyl-CoA as part of heme biosynthesis.

Literature References
Participants
Participant Of
This entity is regulated by: