Reactome: A Curated Pathway Database

Expression of ALAS1 (R-HSA-1592238)

Species Homo sapiens

Summation

The ALAS1 gene is transcribed to yield mRNA and the mRNA is translated in the cytosol to yield precursor protein. The ALAS1 precursor is imported into the mitochodrial matrix where it catalyzes the synthesis of 5-aminolevulinate from glycine and succinyl-CoA as part of heme biosynthesis.

Locations in the PathwayBrowser
Additional Information
Compartment mitochondrial matrix
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This entry is regulated by
Regulation type Name
PositiveRegulation