Reactome: A Curated Pathway Database

Expression of ALAS1 (R-HSA-1592238) [Homo sapiens]

Black Box Event

The ALAS1 gene is transcribed to yield mRNA and the mRNA is translated in the cytosol to yield precursor protein. The ALAS1 precursor is imported into the mitochodrial matrix where it catalyzes the synthesis of 5-aminolevulinate from glycine and succinyl-CoA as part of heme biosynthesis.

Additional Information
Compartment mitochondrial matrix
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