Reactome: A Curated Pathway Database
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Activation of proMMP8

Stable Identifier
R-HSA-1592398
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

proMMP8 is activated by tissue kallikrein, leukocyte elastase, trypsin and cathepsin G (Capodici et al. 1989, Knauper et al. 1990) probably at the predicted bait region, residues 30-36.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
serine-type endopeptidase activity of proMMP8 initial activators [extracellular region] proMMP8 initial activators [extracellular region] serine-type endopeptidase activity (0004252)
Orthologous Events