Reactome: A Curated Pathway Database

Activation of proMMP8 (R-HSA-1592398) [Homo sapiens]

Black Box Event

proMMP8 is activated by tissue kallikrein, leukocyte elastase, trypsin and cathepsin G (Capodici et al. 1989, Knauper et al. 1990) probably at the predicted bait region, residues 30-36.

Additional Information
Compartment extracellular region
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
proMMP8 initial activators serine-type endopeptidase activity (0004252)