Reactome: A Curated Pathway Database

GGCX gamma-carboxylates PROS1(25-676) (pro-protein S)

Stable Identifier
R-HSA-159752
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
pro-protein S, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-protein S + 11 H2O + 11 vitamin K epoxide
Locations in the PathwayBrowser
Summation

GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates eleven glutamate residues on PROS1(25-676) (pro-protein S). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process (Berkner 2000; Furie et al. 1999; Stenina et al. 2001; Morris et al. 1995).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
gamma-glutamyl carboxylase activity of GGCX [endoplasmic reticulum membrane] GGCX [endoplasmic reticulum membrane] gamma-glutamyl carboxylase activity (0008488)
Orthologous Events