Reactome: A Curated Pathway Database

GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (R-HSA-159752) [Homo sapiens]

Reaction
Summation

GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates eleven glutamate residues on PROS1(25-676) (pro-protein S). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process (Berkner 2000; Furie et al. 1999; Stenina et al. 2001; Morris et al. 1995).

Additional Information
Compartment endoplasmic reticulum lumen , endoplasmic reticulum membrane
Catalyst Activity
PhysicalEntity Activity Active Units
GGCX gamma-glutamyl carboxylase activity (0008488)