Reactome: A Curated Pathway Database

pro-protein S, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-protein S + 11 H2O + 11 vitamin K epoxide (R-HSA-159752)

Species Homo sapiens


At the beginning of this reaction, 11 molecules of 'Oxygen', 11 molecules of 'vitamin K hydroquinone', 11 molecules of 'CO2', and 1 molecule of 'pro-protein S, uncarboxylated' are present. At the end of this reaction, 1 molecule of 'pro-protein S', 11 molecules of 'H2O', and 11 molecules of 'vitamin K epoxide' are present.

This reaction takes place in the 'endoplasmic reticulum membrane' and is mediated by the 'gamma-glutamyl carboxylase activity' of 'vitamin K-dependent gamma-carboxylase'.

Locations in the PathwayBrowser
Additional Information
Compartment endoplasmic reticulum lumen , endoplasmic reticulum membrane
Catalyst Activity
PhysicalEntity Activity Active Units
GGCX gamma-glutamyl carboxylase activity (0008488)