Reactome: A Curated Pathway Database

Furin cleaves pro-protein S to protein S (R-HSA-159773) [Homo sapiens]


Furin, associated with the Golgi membrane, cleaves pro-protein S to form mature, gamma-carboxylated protein S (Wasley et al. 1993).

Additional Information
Compartment Golgi lumen , Golgi membrane
Catalyst Activity
PhysicalEntity Activity Active Units
FURIN serine-type endopeptidase activity (0004252)  
Literature References
pubMedId Title Journal Year
8473289 PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway J. Biol. Chem. 1993