Reactome: A Curated Pathway Database

Removal of aminoterminal propeptides from gamma-carboxylated proteins

Stable Identifier
R-HSA-159782
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Furin is an endopeptidase localized to the Golgi membrane that cleaves many proteins on the carboxyterminal side of the sequence motif Arg-[any residue]-(Lys or Arg)-Arg (Jones et al. 1995; Leduc et al. 1992). In the case of gamma-carboxylated proteins, if this cleavage does not occur, the proteins are still secreted but do not function properly (Bristol et al. 1993; Lind et al. 1997; Wasley et al. 1993). The aminoterminal fragments, "propeptides", generated in this reaction have no known function; the carboxylated, cleaved proteins are delivered to the cell membrane or secreted from the cell via pathways to be annotated in a future release of Reactome.

Literature References
Participants
Participant Of
Orthologous Events
Cross References