Activation of proMMP10

Stable Identifier
R-HSA-1602458
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

proMMP10 is similar in sequence to proMMP3 with just one residue difference in the bait region. The activation mechanism is believed to be similar, namely cleavage in the N-terminal bait region, followed by autocatalytic cleavage at His81-Phe82 (Woessner & Nagasse 2000). proMMP10 is activated by plasmin, trypsin and chymotrypsin.

Literature References
PubMed ID Title Journal Year
  Matrix Metalloproteinases and TIMPs   2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of proMMP10 activators [extracellular region]
Physical Entity
Activity
Orthologous Events