Reactome: A Curated Pathway Database

Activation of proMMP10 (R-HSA-1602458) [Homo sapiens]

Black Box Event

proMMP10 is similar in sequence to proMMP3 with just one residue difference in the bait region. The activation mechanism is believed to be similar, namely cleavage in the N-terminal bait region, followed by autocatalytic cleavage at His81-Phe82 (Woessner & Nagasse 2000). proMMP10 is activated by plasmin, trypsin and chymotrypsin.

Additional Information
Compartment extracellular region
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
proMMP10 activators serine-type endopeptidase activity (0004252)  
Literature References
pubMedId Title Journal Year
Matrix Metalloproteinases and TIMPs 2000