Reactome: A Curated Pathway Database

Activation of proMMP10

Stable Identifier
R-HSA-1602458
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

proMMP10 is similar in sequence to proMMP3 with just one residue difference in the bait region. The activation mechanism is believed to be similar, namely cleavage in the N-terminal bait region, followed by autocatalytic cleavage at His81-Phe82 (Woessner & Nagasse 2000). proMMP10 is activated by plasmin, trypsin and chymotrypsin.

Literature References
PubMed ID Title Journal Year
  Matrix Metalloproteinases and TIMPs   2000
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
serine-type endopeptidase activity of proMMP10 activators [extracellular region] proMMP10 activators [extracellular region] serine-type endopeptidase activity (0004252)
Orthologous Events