Reactome | SYNJ1 [cytosol]

SYNJ1 [cytosol]

Stable Identifier

R-HSA-1604634

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

KIAA0910

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
      - SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
      - SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)
      - SYNJs,OCRL [cytosol] (Homo sapiens)
        
        SYNJ1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43426 SYNJ1

Gene Names

SYNJ1, KIAA0910

Chain

chain:1-1573

Reference Genes

BioGPS Gene:8867 SYNJ1

COSMIC (genes):SYNJ1 SYNJ1

CTD Gene:8867 SYNJ1

dbSNP Gene:8867 SYNJ1

ENSEMBL:ENSG00000159082 SYNJ1

ENSEMBL_homo_sapiens_GENE:ENSG00000159082.18 SYNJ1

HGNC:11503 SYNJ1

KEGG Gene (Homo sapiens):8867 SYNJ1

Monarch:8867 SYNJ1

NCBI Gene:8867 SYNJ1

OMIM:604297 SYNJ1

UCSC:O43426 SYNJ1

Reference Transcript

Other Identifiers

11723867_a_at

11723868_a_at

11745278_a_at

11745279_a_at

16925057

207594_PM_s_at

207594_s_at

212990_PM_at

212990_at

3929326

3929327

3929328

3929329

3929330

3929331

3929332

3929334

3929335

3929336

3929337

3929339

3929341

3929342

3929343

3929344

3929346

3929347

3929348

3929350

3929351

3929354

3929357

3929360

3929361

3929362

3929364

3929366

3929367

3929368

3929372

3929373

3929374

3929377

3929379

3929380

3929381

3929382

3929384

3929385

3929386

3929389

3929390

41692_at

8070010

8867

A_23_P102884

A_23_P324718

GE53578

GE81333

GE86488

GO:0003676

GO:0003723

GO:0003824

GO:0004438

GO:0004439

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0006629

GO:0006661

GO:0006836

GO:0006897

GO:0007612

GO:0012506

GO:0016082

GO:0016191

GO:0016192

GO:0016787

GO:0016791

GO:0017124

GO:0023052

GO:0030117

GO:0030132

GO:0034595

GO:0034596

GO:0036092

GO:0043195

GO:0043226

GO:0043647

GO:0043812

GO:0043813

GO:0046488

GO:0046856

GO:0048471

GO:0048488

GO:0048489

GO:0050877

GO:0052629

GO:0052658

GO:0052866

GO:0061024

GO:0065003

GO:0097060

GO:0098793

GO:1904980

HMNXSV003041692

HMNXSV003048451

Hs.127416.2.S1_3p_at

ILMN_1701991

ILMN_1762303

ILMN_2393968

PH_hs_0019097

TC21000400.hg

g4507334_3p_a_at

Participates

as a member of

Inferred To

Synj [cytosol] (Drosophila melanogaster)

syj1 [cytosol] (Schizosaccharomyces pombe)

synj1 [cytosol] (Xenopus tropicalis)

Dd5P3 [cytosol] (Dictyostelium discoideum)

INP53 [cytosol] (Saccharomyces cerevisiae)

unc-26 [cytosol] (Caenorhabditis elegans)

Synj1 [cytosol] (Mus musculus)

Synj1 [cytosol] (Rattus norvegicus)

SYNJ1 [cytosol] (Bos taurus)

SYNJ1 [cytosol] (Canis familiaris)

SYNJ1 [cytosol] (Gallus gallus)

SYNJ1 [cytosol] (Plasmodium falciparum)

SYNJ1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_982271.2, NP_001153778.1, NP_003886.3, NP_001153774.1, XP_016883989.1

Guide to Pharmacology - Targets

1461

OpenTargets

ENSG00000159082

GeneCards

O43426

HPA

ENSG00000159082-SYNJ1

Ensembl

ENST00000357345, ENSG00000159082, ENSP00000349903, ENST00000674351, ENSP00000501426, ENSP00000501504, ENSP00000501530, ENST00000674308, ENST00000674204

PRO

O43426

Pharos - Targets

O43426

Orphanet

22665

HMDB Protein

HMDBP01573

PDB

7A0V, 2VJ0, 2DNR, 1W80

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.573	2
UniProt:P62994 Grb2	3	Grb2 [cytosol] (R-RNO-55929) Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-74686)	0.558	2
UniProt:Q99962 SH3GL2	4	SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189)	0.558	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2

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