Reactome: A Curated Pathway Database

Steryl sulfatase hydrolyses sulfate from steroid sulfates

Stable Identifier
R-HSA-1606839
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Steryl sulfatase (formerly arylsulfatase C, ARSC) hydrolyses sulfate from steroid sulfates (Noel et al. 1983, Vaccaro et al. 1987, Suzuki et al. 1992). It is located on the ER membrane (Stein et al. 1989) and functions as a homodimer, using calcium as a cofactor. Defects in STS are the cause of ichthyosis X-linked (IXL) (MIM:308100), a keratinisation disorder (Basler et al. 1992, Alperin & Shapiro 1997).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
steryl-sulfatase activity of active STS dimer [endoplasmic reticulum membrane] active STS dimer [endoplasmic reticulum membrane] steryl-sulfatase activity (0004773)
Orthologous Events
Cross References
Rhea