Reactome: A Curated Pathway Database

Steryl sulfatase hydrolyses sulfate from steroid sulfates (R-HSA-1606839)

Species Homo sapiens


Steryl sulfatase (formerly arylsulfatase C, ARSC) hydrolyses sulfate from steroid sulfates (Noel et al. 1983, Vaccaro et al. 1987, Suzuki et al. 1992). It is located on the ER membrane (Stein et al. 1989) and functions as a homodimer, using calcium as a cofactor. Defects in STS are the cause of ichthyosis X-linked (IXL) (MIM:308100), a keratinisation disorder (Basler et al. 1992, Alperin & Shapiro 1997).

Locations in the PathwayBrowser
Additional Information
Compartment endoplasmic reticulum membrane , endoplasmic reticulum lumen
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
active STS dimer steryl-sulfatase activity (0004773)
Cross References
Database Identifier
Rhea 19876, 19874
This entry is regulated by
Regulation type Name