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Steryl sulfatase hydrolyses sulfate from steroid sulfates

Stable Identifier
R-HSA-1606839
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Steryl sulfatase (formerly arylsulfatase C, ARSC) hydrolyses sulfate from steroid sulfates (Noel et al. 1983, Vaccaro et al. 1987, Suzuki et al. 1992). It is located on the ER membrane (Stein et al. 1989) and functions as a homodimer, using calcium as a cofactor. Defects in STS are the cause of ichthyosis X-linked (IXL) (MIM:308100), a keratinisation disorder (Basler et al. 1992, Alperin & Shapiro 1997).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
steryl-sulfatase activity of active STS dimer [endoplasmic reticulum membrane]
Physical Entity
Activity
This entity is regulated by
Orthologous Events
Cross References
Rhea