Reactome: A Curated Pathway Database

Sulfide oxidation to sulfate (R-HSA-1614517) [Homo sapiens]


While the human body is very economical with sulfur amino acids (SAA), superfluous SAA are degraded via cysteine to toxic hydrogen sulfide which must be dealt with. The pathway to oxidize this gas is localized to mitochondria and is highly conserved, pointing back to a time when life was immersed in sulfide-rich waters.
The pathway for sulfide oxidation consists of five reactions, one of which, the sulfur transfer from thiosulfate to glutathione, is still to be characterized fully. A mutation in one enzyme has been identified that is associated with ethylmalonyl encephalopathy and where tissue sulfide is elevated (Stipanuk & Ueki 2011).

Additional Information
GO Biological Process sulfide oxidation, using sulfide:quinone oxidoreductase (0070221)
Literature References
pubMedId Title Journal Year
20162368 Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur J Inherit Metab Dis 2011