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Sulfide oxidation to sulfate
Stable Identifier
R-HSA-1614517
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Sulfur amino acid metabolism (Homo sapiens)
Degradation of cysteine and homocysteine (Homo sapiens)
Sulfide oxidation to sulfate (Homo sapiens)
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While the human body is very economical with sulfur amino acids (SAA), superfluous SAA are degraded via cysteine to toxic hydrogen sulfide which must be dealt with. The pathway to oxidize this gas is localized to mitochondria and is highly conserved, pointing back to a time when life was immersed in sulfide-rich waters.
The pathway for sulfide oxidation consists of five reactions, one of which, the sulfur transfer from thiosulfate to glutathione, is still to be characterized fully. A mutation in one enzyme has been identified that is associated with ethylmalonyl encephalopathy and where tissue sulfide is elevated (Stipanuk & Ueki 2011).
Literature References
PubMed ID
Title
Journal
Year
20162368
Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur
Ueki, I
,
Stipanuk, MH
J Inherit Metab Dis
2011
Participants
Events
SQR oxidizes sulfide to bound persulfide
(Homo sapiens)
Persulfide sulfur is dioxygenated
(Homo sapiens)
Persulfide sulfur is transferred onto sulfite
(Homo sapiens)
Thiosulfate can transfer its sulfur atom to glutathione
(Homo sapiens)
Sulfite is oxidized to sulfate
(Homo sapiens)
Sulfate is exported to the cytosol in exchange for dicarboxylate
(Homo sapiens)
Participates
as an event of
Degradation of cysteine and homocysteine (Homo sapiens)
Event Information
Go Biological Process
sulfide oxidation, using sulfide:quinone oxidoreductase (0070221)
Orthologous Events
Sulfide oxidation to sulfate (Bos taurus)
Sulfide oxidation to sulfate (Caenorhabditis elegans)
Sulfide oxidation to sulfate (Canis familiaris)
Sulfide oxidation to sulfate (Danio rerio)
Sulfide oxidation to sulfate (Dictyostelium discoideum)
Sulfide oxidation to sulfate (Drosophila melanogaster)
Sulfide oxidation to sulfate (Gallus gallus)
Sulfide oxidation to sulfate (Mus musculus)
Sulfide oxidation to sulfate (Rattus norvegicus)
Sulfide oxidation to sulfate (Saccharomyces cerevisiae)
Sulfide oxidation to sulfate (Sus scrofa)
Sulfide oxidation to sulfate (Xenopus tropicalis)
Authored
Stephan, R (2010-10-24)
Reviewed
D'Eustachio, P (2011-10-13)
Created
Jassal, B (2011-09-29)
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