Reactome: A Curated Pathway Database

Excess cysteine yields lanthionine and H2S (R-HSA-1614591)

Species Homo sapiens


Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

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Compartment cytosol
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Catalyst Activity
PhysicalEntity Activity Active Units
CTH tetramer:PXLP L-cysteine desulfhydrase activity (0080146)
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Regulation type Name