Reactome will be unavailable due to host maintenance from Friday, April 27 at 6pm to Sunday, April 29 at 11:55pm.

During the outage, you may wish to use our mirror site at reactome.ncpsb.org.

Excess cysteine yields lanthionine and H2S

Stable Identifier
R-HSA-1614591
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

Participants
Input
Participant Of
Catalyst Activity
Catalyst Activity
Title
L-cysteine desulfhydrase activity of CTH tetramer:PXLP [cytosol]
Physical Entity
Activity
This entity is regulated by
Orthologous Events