Reactome: A Curated Pathway Database

Excess cysteine yields lanthionine and H2S

Stable Identifier
R-HSA-1614591
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

Literature References
Participants
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Participant Of
This entity is regulated by:
Title Physical Entity Activity
L-cysteine desulfhydrase activity of CTH tetramer:PXLP [cytosol] CTH tetramer:PXLP [cytosol] L-cysteine desulfhydrase activity (0080146)
Orthologous Events