Reactome: A Curated Pathway Database

Cysteine is degraded to serine and H2S

Stable Identifier
R-HSA-1614614
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

alpha,beta-elimination activity of cystathionine-gamma-lyase (CTH) replaces the sulfur in cysteine with oxygen from water, resulting in serine and toxic hydrogen sulfide, which is further oxidized in mitochondria (Chiku et al. 2009, Steegborn et al. 1999).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
L-cysteine desulfhydrase activity of CTH tetramer:PXLP [cytosol] CTH tetramer:PXLP [cytosol] L-cysteine desulfhydrase activity (0080146)
Orthologous Events