Cysteine is degraded to serine and H2S

Stable Identifier
R-HSA-1614614
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

alpha,beta-elimination activity of cystathionine-gamma-lyase (CTH) replaces the sulfur in cysteine with oxygen from water, resulting in serine and toxic hydrogen sulfide, which is further oxidized in mitochondria (Chiku et al. 2009, Steegborn et al. 1999).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
L-cysteine desulfhydrase activity of CTH tetramer:PXLP [cytosol]
Physical Entity
Activity
Orthologous Events