Reactome: A Curated Pathway Database

Cysteine is degraded to serine and H2S (R-HSA-1614614)

Species Homo sapiens


alpha,beta-elimination activity of cystathionine-gamma-lyase (CTH) replaces the sulfur in cysteine with oxygen from water, resulting in serine and toxic hydrogen sulfide, which is further oxidized in mitochondria (Chiku et al. 2009, Steegborn et al. 1999).

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Compartment cytosol
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Catalyst Activity
PhysicalEntity Activity Active Units
CTH tetramer:PXLP L-cysteine desulfhydrase activity (0080146)