Reactome: A Curated Pathway Database

Cysteine is degraded to serine and H2S (R-HSA-1614614)

Species Homo sapiens

Summation

alpha,beta-elimination activity of cystathionine-gamma-lyase (CTH) replaces the sulfur in cysteine with oxygen from water, resulting in serine and toxic hydrogen sulfide, which is further oxidized in mitochondria (Chiku et al. 2009, Steegborn et al. 1999).

Locations in the PathwayBrowser
Additional Information
Compartment cytosol
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
CTH tetramer:PXLP L-cysteine desulfhydrase activity (0080146)