alpha,beta-elimination activity of cystathionine-gamma-lyase (CTH) replaces the sulfur in cysteine with oxygen from water, resulting in serine and toxic hydrogen sulfide, which is further oxidized in mitochondria (Chiku et al. 2009, Steegborn et al. 1999).
|CTH tetramer:PXLP||L-cysteine desulfhydrase activity (0080146)|
|19261609||H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia||J Biol Chem||2009|
|10212249||Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration||J Biol Chem||1999|