Budding and maturation of HIV virion

Stable Identifier
Homo sapiens
Related Species
Human immunodeficiency virus 1
Locations in the PathwayBrowser

With the virus components precariously assembled on the inner leaflet of the plasma membrane, the host cell machinery is required for viral budding. The virus takes advantage of the host ESCRT pathway to terminate Gag polymerization and catalyze release. The ESCRT pathway is normally responsible for membrane fission that creates cytoplasm filled vesicular bodies. In this case HIV (and other viruses) take advantage of the ESCRT cellular machinery to facilitate virion budding from the host.

Literature References
PubMed ID Title Journal Year
22762019 HIV-1 Assembly, Budding, and Maturation Cold Spring Harb Perspect Med 2012
Participant Of
Event Information
Go Biological Process
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Cross References
BioModels Database