Reactome: A Curated Pathway Database

Budding and maturation of HIV virion

Stable Identifier
R-HSA-162588
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

With the virus components precariously assembled on the inner leaflet of the plasma membrane, the host cell machinery is required for viral budding. The virus takes advantage of the host ESCRT pathway to terminate Gag polymerization and catalyze release. The ESCRT pathway is normally responsible for membrane fission that creates cytoplasm filled vesicular bodies. In this case HIV (and other viruses) take advantage of the ESCRT cellular machinery to facilitate virion budding from the host.

Literature References
PubMed ID Title Journal Year
22762019 HIV-1 Assembly, Budding, and Maturation Cold Spring Harb Perspect Med 2012
Participants
Participant Of
Disease
Diseases
Name Identifier Synonyms
Cross References
BioModels Database