Reactome: A Curated Pathway Database

Budding and maturation of HIV virion (R-HSA-162588) [Homo sapiens]


With the virus components precariously assembled on the inner leaflet of the plasma membrane, the host cell machinery is required for viral budding. The virus takes advantage of the host ESCRT pathway to terminate Gag polymerization and catalyze release. The ESCRT pathway is normally responsible for membrane fission that creates cytoplasm filled vesicular bodies. In this case HIV (and other viruses) take advantage of the ESCRT cellular machinery to facilitate virion budding from the host.

Additional Information
GO Biological Process viral life cycle (0019058)
Cross References
Database Identifier
BioModels Database BIOMD0000000220, BIOMD0000000293
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 [HIV infection]
Literature References
pubMedId Title Journal Year
22762019 HIV-1 Assembly, Budding, and Maturation Cold Spring Harb Perspect Med 2012