We will be undergoing a brief scheduled maintenance at Monday Jan 22 at 10AM EST - you may experience some outages

We will be undergoing a scheduled maintenance at Monday Jan 22 at 10AM EST

Early Phase of HIV Life Cycle

Stable Identifier
Homo sapiens
Related Species
Human immunodeficiency virus 1
Locations in the PathwayBrowser

In the early phase of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core is uncoated to expose a viral nucleoprotein complex containing RNA and viral proteins. HIV RNA genome is reverse transcribed by the viral Reverse Transcriptase to form a cDNA copy, that gets inserted into host cell DNA. The viral Integrase enzyme is vital to carry out the integration of the viral cDNA into the host genome. The host DNA repair enzymes probably repair the breaks in DNA at the sites of integration.

Literature References
Participant Of
Event Information
Go Biological Process
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection