Reactome: A Curated Pathway Database

HIV Infection (R-HSA-162906)

Species Homo sapiens

Summation

The global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million HIV/AIDS patients worldwide with 75% of them living in sub-Saharan Africa. The primary method of HIV infection is by sexual exposure while nonsexual HIV transmission also can occur through transfusion with contaminated blood products, injection drug use, occupational exposure,accidental needlesticks or mother-to-child transmission. HIV damages the immune system, leaving the infected person vulnerable to a variety of "opportunistic" infections arising from host immune impairment (Hare, 2004).
HIV-1 and the less common HIV-2 belong to the family of retroviruses. HIV-1 contains a single-stranded RNA genome that is 9 kilobases in length and contains 9 genes that encode 15 different proteins. These proteins are classified as: structural proteins (Gag, Pol, and Env), regulatory proteins (Tat and Rev), and accessory proteins (Vpu, Vpr, Vif, and Nef) (Frankel and Young,1998).
HIV infection cycle can be divided into two phases:
1. An Early phase consisting of early events occuring after HIV infection of a susceptible target cell and a
2. Late phase comprising the later events in the HIV-infected cell resulting in the assembly of new infectious virions. The section titled HIV lifecycle consists of annotations of events in these two phases.
The virus has developed various molecular strategies to suppress the antiviral immune responses (innate, cellular and humoral) of the host. HIV-1 viral auxiliary proteins (Tat, Rev, Nef, Vif, Vpr and Vpu) play important roles in these host-pathogen interactions (Li et al.,2005). The section titled Host interactions of HIV factors will highlight these complex post-infection processes and the annotations will be released in near future.

Locations in the PathwayBrowser
Additional Information
GO Biological Process viral process (0016032)
Diseases
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 [HIV infection]
Literature References
pubMedId Title Journal Year
Clinical Overview of HIV Disease HIV InSite knowledgebase (http://hivinsite.ucsf.edu/InSite?page=kb-03-01-01) 2004
9759480 HIV-1: fifteen proteins and an RNA Annu Rev Biochem 1998
16354571 Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions Cell Res 2005