Reactome: A Curated Pathway Database

Elongation Of The Telomeric Chromosome End (R-HSA-163090) [Homo sapiens]


The template of hTERC directs the sequential addition of nucleotides to the 3' telomeric DNA end. Following addition of a nucleotide, the template and catalytic site must move relative to one another within the telomerase RNP to place the appropriate template residue in the active site. As base-pairing and nucleotide addition occur at one end of the template, base pair melting occurs at the other (Collins and Greider 1993; Wang and Blackburn, 1997; Hammond and Cech 1998; Benjamin et al. 2000; Forstemann and Lingner 2005). This un-pairing is thought to reduce the energy used for mediating the subsequent translocation step. Nucleotide addition can occur up until the template boundary which in hTERC is defined by a helix called P1b (Chen and Greider 2003).

Additional Information
Compartment nucleoplasm
GO Biological Process telomere maintenance via telomerase (0007004)
Catalyst Activity
PhysicalEntity Activity Active Units
Telomerase RNP telomerase activity (0003720)
Literature References
pubMedId Title Journal Year
15189140 Regulation of telomerase by telomeric proteins Annu Rev Biochem 2004