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Disassociation of Telomerase RNP and the Chromosome End

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

In vitro, telomerase can disassociate from the primer following addition of each nucleotide or during the translocation step. The regulation of telomerase disassociation from the telomere in vivo is not well-characterized. One factor that may be involved is a helicase termed hPIF1, which can unanneal the telomerase RNA/telomeric DNA hybrid (Boule et al., 2005; Zhang et al., 2006).

Literature References
PubMed ID Title Journal Year
15189140 Regulation of telomerase by telomeric proteins Annu Rev Biochem 2004
Participant Of
Event Information
Orthologous Events