Reactome: A Curated Pathway Database

Disassociation of Telomerase RNP and the Chromosome End

Stable Identifier
R-HSA-163120
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In vitro, telomerase can disassociate from the primer following addition of each nucleotide or during the translocation step. The regulation of telomerase disassociation from the telomere in vivo is not well-characterized. One factor that may be involved is a helicase termed hPIF1, which can unanneal the telomerase RNA/telomeric DNA hybrid (Boule et al., 2005; Zhang et al., 2006).

Literature References
PubMed ID Title Journal Year
15189140 Regulation of telomerase by telomeric proteins Annu Rev Biochem 2004
Participants
Participant Of
Orthologous Events