Reactome: A Curated Pathway Database

Disassociation of Telomerase RNP and the Chromosome End (R-HSA-163120) [Homo sapiens]


In vitro, telomerase can disassociate from the primer following addition of each nucleotide or during the translocation step. The regulation of telomerase disassociation from the telomere in vivo is not well-characterized. One factor that may be involved is a helicase termed hPIF1, which can unanneal the telomerase RNA/telomeric DNA hybrid (Boule et al., 2005; Zhang et al., 2006).

Additional Information
Compartment nucleoplasm
GO Biological Process telomere maintenance via telomerase (0007004)
Literature References
pubMedId Title Journal Year
15189140 Regulation of telomerase by telomeric proteins Annu Rev Biochem 2004