Disassociation of Telomerase RNP and the Chromosome End

Stable Identifier
R-HSA-163120
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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Summation

In vitro, telomerase can disassociate from the primer following addition of each nucleotide or during the translocation step. The regulation of telomerase disassociation from the telomere in vivo is not well-characterized. One factor that may be involved is a helicase termed hPIF1, which can unanneal the telomerase RNA/telomeric DNA hybrid (Boule et al., 2005; Zhang et al., 2006).

Literature References
PubMed ID Title Journal Year
15189140 Regulation of telomerase by telomeric proteins Annu Rev Biochem 2004
Participants
Input
Output
Participant Of
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Event Information
Go Biological Process
telomere maintenance via telomerase (0007004)
Orthologous Events
Disassociation of Telomerase RNP and the Chromosome End (Arabidopsis thaliana)
Disassociation of Telomerase RNP and the Chromosome End (Bos taurus)
Disassociation of Telomerase RNP and the Chromosome End (Canis familiaris)
Disassociation of Telomerase RNP and the Chromosome End (Danio rerio)
Disassociation of Telomerase RNP and the Chromosome End (Dictyostelium discoideum)
Disassociation of Telomerase RNP and the Chromosome End (Gallus gallus)
Disassociation of Telomerase RNP and the Chromosome End (Mus musculus)
Disassociation of Telomerase RNP and the Chromosome End (Rattus norvegicus)
Disassociation of Telomerase RNP and the Chromosome End (Saccharomyces cerevisiae)
Disassociation of Telomerase RNP and the Chromosome End (Schizosaccharomyces pombe)
Disassociation of Telomerase RNP and the Chromosome End (Sus scrofa)
Disassociation of Telomerase RNP and the Chromosome End (Taeniopygia guttata)
Disassociation of Telomerase RNP and the Chromosome End (Xenopus tropicalis)
Dissociation of telomerase RNP from the extended chromosomal end (Gallus gallus)