Reactome: A Curated Pathway Database

Post-translational modification: synthesis of GPI-anchored proteins (R-HSA-163125)

Species Homo sapiens

Summation

Glycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactions appears to be responsible for the synthesis of the major GPI species involved in membrane protein anchoring.

As a nascent protein fated to become GPI-anchored moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves it near its carboxy terminus and attaches an acylated GPI moiety. The GPI moiety is deacylated, yielding a protein-GPI conjugate that can be efficiently transported to the Golgi apparatus.

Locations in the PathwayBrowser
Additional Information
GO Biological Process C-terminal protein lipidation (0006501)
Inferred Entries
Orthologous events