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Formation of ATP by chemiosmotic coupling
Stable Identifier
R-HSA-163210
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Formation of ATP by chemiosmotic coupling (Homo sapiens)
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The re-entry of protons into the mitochondrial matrix through Complex V causes conformational changes which result in ATP synthesis. Complex V (ATP synthase) is composed of 3 parts; an F1 catalytic core (approx 5 subunits), an F0 membrane proton channel (approx 9 subunits) and two stalks linking F1 to F0. F1 contains three alpha subunits, three beta subunits, and one each of gamma, delta, and epsilon subunits. Each beta subunit contains an active site for ATP synthesis. F0 has at least 9 subunits (a-g, A6L and F6), with one copy each of subunits b, d and F6.
The mechanism of ATP synthesis by Complex V was predicted by Boyer et al in 1973: ADP and Pi bind to the enzyme resulting in a conformational change. ATP is then synthesized, still bound to the enzyme. Another change in the active site results in the release of free ATP into the matrix. The overall reaction is:
ADP + Pi + H+ + nH+ (intermemb. space) = ATP + H2O + nH+ (matrix)
Literature References
PubMed ID
Title
Journal
Year
4517936
A new concept for energy coupling in oxidative phosphorylation based on a
Boyer, PD
,
Momsen, W
,
Cross, RL
Proc Natl Acad Sci U S A
1973
Participants
Events
ADP and Pi bind to ATPase
(Homo sapiens)
ATPase synthesizes ATP
(Homo sapiens)
Enzyme-bound ATP is released
(Homo sapiens)
Participates
as an event of
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Event Information
Go Biological Process
proton motive force-driven mitochondrial ATP synthesis (0042776)
Orthologous Events
Formation of ATP by chemiosmotic coupling (Bos taurus)
Formation of ATP by chemiosmotic coupling (Caenorhabditis elegans)
Formation of ATP by chemiosmotic coupling (Canis familiaris)
Formation of ATP by chemiosmotic coupling (Danio rerio)
Formation of ATP by chemiosmotic coupling (Drosophila melanogaster)
Formation of ATP by chemiosmotic coupling (Gallus gallus)
Formation of ATP by chemiosmotic coupling (Mus musculus)
Formation of ATP by chemiosmotic coupling (Rattus norvegicus)
Formation of ATP by chemiosmotic coupling (Saccharomyces cerevisiae)
Formation of ATP by chemiosmotic coupling (Sus scrofa)
Authored
Jassal, B (2005-06-29)
Created
Jassal, B (2005-04-25)
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