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PKA-mediated phosphorylation of key metabolic factors

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Upon dissociation of protein kinase A (PKA) tetramers in the presence of cAMP, the released PKA catalytic monomers phosphorylate specific serine and threonine residues of several metabolic enzymes. These target enzymes include glycogen phosphorylase kinase, glycogen synthase and PF2K-Pase. PKA also phosphorylates ChREBP (Carbohydrate Response Element Binding Protein), preventing its movement into the nucleus and thus its function as a positive transcription factor for genes involved in glycolytic and lipogenic reactions.

Literature References
PubMed ID Title Journal Year
12721358 A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis Proc Natl Acad Sci U S A 2003
Participant Of
Event Information
Orthologous Events