Reactome: A Curated Pathway Database

PKA-mediated phosphorylation of key metabolic factors

Stable Identifier
R-HSA-163358
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Upon dissociation of protein kinase A (PKA) tetramers in the presence of cAMP, the released PKA catalytic monomers phosphorylate specific serine and threonine residues of several metabolic enzymes. These target enzymes include glycogen phosphorylase kinase, glycogen synthase and PF2K-Pase. PKA also phosphorylates ChREBP (Carbohydrate Response Element Binding Protein), preventing its movement into the nucleus and thus its function as a positive transcription factor for genes involved in glycolytic and lipogenic reactions.

Literature References
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Orthologous Events