Reactome: A Curated Pathway Database

PKA activation

Stable Identifier
R-HSA-163615
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

A number of inactive tetrameric PKA holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. When cAMP binds to two specific binding sites on the regulatory subunits, these undergo a conformational change that causes the dissociation of a dimer of regulatory subunits bound to four cAMP from two monomeric, catalytically active PKA subunits.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events