Reactome: A Curated Pathway Database

PKA activation (R-HSA-163615) [Homo sapiens]


A number of inactive tetrameric PKA holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. When cAMP binds to two specific binding sites on the regulatory subunits, these undergo a conformational change that causes the dissociation of a dimer of regulatory subunits bound to four cAMP from two monomeric, catalytically active PKA subunits.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane , cytosol
GO Biological Process activation of protein kinase A activity (0034199)
Literature References
pubMedId Title Journal Year
2165385 cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes Annu Rev Biochem 1990