AMP-activated protein kinase (AMPK) is a sensor of cellular energy levels. A high cellular ratio of AMP:ATP triggers the phosphorylation and activation of AMPK. Activated AMPK in turn phosphorylates a wide array of target proteins, as shown in the figure below (reproduced from (Hardie et al. 2003), with the permission of D.G. Hardie). These targets include ChREBP (Carbohydrate Response Element Binding Protein), whose inactivation by phosphorylation reduces transcription of key enzymes of the glycolytic and lipogenic pathways.
|GO Biological Process||regulation of fatty acid biosynthetic process (0042304)|
|11724780||Mechanism for fatty acid sparing effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase||J Biol Chem||2002|
|10698692||Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding||Biochem J||2000|
|12829246||Management of cellular energy by the AMP-activated protein kinase system||FEBS Lett||2003|
|15509864||The AMP-activated protein kinase pathway--new players upstream and downstream||J Cell Sci||2004|