Dimeric cytosolic transaldolase (TALDO1) catalyzes the reversible reaction of D-erythrose 4-phosphate and D-fructose 6-phosphate to form D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate. Protein expressed from the cloned gene has been characterized biochemically and crystallographically (Banki et al. 1994; Thorell et al. 2000) and transaldolase deficiency in a patient has been correlated with a mutation in the TALDO1 gene (Verhoeven et al. 2001).
|Reverse Reaction||sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate|
|TALDO1 dimer||sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity (0004801)|
|8300619||Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence||J Biol Chem||1994|
|10869557||The three-dimensional structure of human transaldolase||FEBS Lett.||2000|
|11283793||Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway.||Am J Hum Genet||2001|