Reactome: A Curated Pathway Database

D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate

Stable Identifier
R-HSA-163764
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
TALDO1 transforms Fru(6)P and E4P to sedoheptulose 7-phosphate and GA3P
Locations in the PathwayBrowser
Summation

Dimeric cytosolic transaldolase (TALDO1) catalyzes the reversible reaction of D-erythrose 4-phosphate and D-fructose 6-phosphate to form D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate. Protein expressed from the cloned gene has been characterized biochemically and crystallographically (Banki et al. 1994; Thorell et al. 2000) and transaldolase deficiency in a patient has been correlated with a mutation in the TALDO1 gene (Verhoeven et al. 2001).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity of TALDO1 dimer [cytosol] TALDO1 dimer [cytosol] sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity (0004801)
Orthologous Events