Reactome: A Curated Pathway Database

PP2A-mediated dephosphorylation of key metabolic factors (R-HSA-163767)

Species Homo sapiens


A member of the PP2A family of phosphatases dephosphorylates both cytosolic and nuclear forms of ChREBP (Carbohydrate Response Elemant Binding Protein). In the nucleus, dephosphorylated ChREBP complexes with MLX protein and binds to ChRE sequence elements in chromosomal DNA, activating transcription of genes involved in glycolysis and lipogenesis. The phosphatase is activated by Xylulose-5-phosphate, an intermediate of the pentose phosphate pathway (Kabashima et al. 2003). The rat enzyme has been purified to homogeneity and shown by partial amino acid sequence analysis to differ from previously described PP2A phosphatases (Nishimura and Uyeda 1995) - the human enzyme has not been characterized.

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Additional Information
Compartment cytosol , nucleoplasm
Literature References
pubMedId Title Journal Year
12721358 A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis Proc Natl Acad Sci U S A 2003