Reactome: A Curated Pathway Database

LKB1 phosphorylates the alpha subunit of AMPK heterotrimer

Stable Identifier
R-HSA-164151
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

LKB1 phosphorylates threonine residue 172 of the alpha subunit of the AMPK heterotrimer, activating it. LKB1, a serine/threonine kinase, was first identified as the gene whose mutation is associated with the Peutz-Jeghers familial cancer syndrome. This disease phenotype is consistent with the hypothesis that the interaction between LKB1 and AMPK normally plays a key role in the negative regulation of cell growth (Hardie 2004).

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein kinase activity of STK11 [nucleoplasm] STK11 [nucleoplasm] protein kinase activity (0004672)
Inferred From