Reactome: A Curated Pathway Database

Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (R-HSA-164620)

Species Homo sapiens

Summation

The human telomerase RNP can catalyze multiple rounds of repeat addition on the same telomeric substrate in vitro. Before initiating synthesis of another repeat, telomerase undergoes a translocation step to reposition itself on the telomere. Base pairs in the DNA/RNA hybrid are unannealed, the RNA template is repositioned relative to the active site, and the template base-pairs at the 3' end of the newly synthesized DNA. The anchor site interaction with DNA 5' of the RNA-DNA duplex is thought to maintain the interaction of telomerase with DNA during the translocation step.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
GO Biological Process telomere maintenance via telomerase (0007004)
Literature References
pubMedId Title Journal Year
15189140 Regulation of telomerase by telomeric proteins Annu Rev Biochem 2004
Inferred Entries
Orthologous events