Reactome: A Curated Pathway Database

Nef mediated downregulation of MHC class I complex cell surface expression

Stable Identifier
R-HSA-164940
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Down-regulation of MHC class I involves Nef-mediated connection in the endosomes between MHC-I's cytoplasmic tail and the phosphofurin acidic cluster sorting protein-1 (PACS-1)-dependent protein-sorting pathway. Down-regulation of MHC I protects HIV-infected cells from host CTL response.

Literature References
Participants
Participant Of
Disease
Diseases
Name Identifier Synonyms