Nef mediated downregulation of MHC class I complex cell surface expression

Stable Identifier
R-HSA-164940
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Locations in the PathwayBrowser
Summation

Down-regulation of MHC class I involves Nef-mediated connection in the endosomes between MHC-I's cytoplasmic tail and the phosphofurin acidic cluster sorting protein-1 (PACS-1)-dependent protein-sorting pathway. Down-regulation of MHC I protects HIV-infected cells from host CTL response.

Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection