Expression of Fatty Acid Synthase (FASN)

Stable Identifier
R-HSA-1655843
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Expression of Fatty Acid Synthase (FASN)
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SREBF1A (SREBP1A) and SREBF1C (SREBP1C) bind the promoter of the fatty acid synthase gene (FASN) and enhance transcription (Bennett et al. 1995, Magana and Osborne 1996, Shimano et al. 1996, Boizard et al. 1998, Foretz et al. 1999, Shimano et al. 1999, Amemiya-Kudo et al. 2002, Griffin et al. 2007, Choi et al. 2008, Rome et al. 2008, reviewed in Horton et al. 2002). The enhancer activity of SREBF1 requires simultaneous binding of NF-Y and SP1 to the promoter (Xiong et al. 2000). The FASN gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
Literature References
PubMed ID Title Journal Year
7567999 Human fatty acid synthase: properties and molecular cloning

Jayakumar, A, Wakil, SJ, Huang, WY, Hsu, M, Chirala, SS, al-Feel, W, Abu-Elheiga, L, Tai, MH

Proc Natl Acad Sci U S A 1995
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This event is regulated
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Regulator
SREBP1A,1C:NF-Y:SP1:FASN gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-09-28)
Reviewed
Liang, G  (2012-08-26)
Created
May, B  (2011-10-13)
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