Reactome: A Curated Pathway Database

The activation of arylsulfatases

Stable Identifier
R-HSA-1663150
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Sulfatase activity requires a unique posttranslational modification (PTM) of a catalytic cysteine residue into a formylglycine. This modification is impaired in patients with multiple sulfatase deficiency (MSD) due to defects in the SUMF1 (sulfatase-modifying factor 1) gene responsible for this PTM. SUMF2 can inhibit the activity of SUMF1 thereby providing a mechanism for the regulation of sulfatase activation (Ghosh 2007, Diez-Roux & Ballabio 2005).

Literature References
PubMed ID Title Journal Year
17558559 Human sulfatases: a structural perspective to catalysis Cell Mol Life Sci 2007
16124866 Sulfatases and human disease Annu Rev Genomics Hum Genet 2005
Participants
Participant Of
Orthologous Events