Reactome: A Curated Pathway Database

PLC-gamma1 signalling

Stable Identifier
R-HSA-167021
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosphorylation by TrkA receptor kinase and this form hydrolyses PIP2 to generate inositol tris-phosphate (IP3) and diacylglycerol (DAG). IP3 promotes the release of Ca2+ from internal stores and this results in activation of enzymes such as protein kinase C and Ca2+ calmodulin-regulated protein kinases.

Literature References
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