Reactome: A Curated Pathway Database

PLC-gamma1 signalling (R-HSA-167021) [Homo sapiens]


The activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosphorylation by TrkA receptor kinase and this form hydrolyses PIP2 to generate inositol tris-phosphate (IP3) and diacylglycerol (DAG). IP3 promotes the release of Ca2+ from internal stores and this results in activation of enzymes such as protein kinase C and Ca2+ calmodulin-regulated protein kinases.

Additional Information
GO Biological Process activation of phospholipase C activity (0007202)
Literature References
pubMedId Title Journal Year
12676795 Trk receptors: roles in neuronal signal transduction Annu Rev Biochem 2003
10579907 Phospholipase C-gamma as a signal-transducing element Exp Cell Res 1999