The activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosphorylation by TrkA receptor kinase and this form hydrolyses PIP2 to generate inositol tris-phosphate (IP3) and diacylglycerol (DAG). IP3 promotes the release of Ca2+ from internal stores and this results in activation of enzymes such as protein kinase C and Ca2+ calmodulin-regulated protein kinases.
|GO Biological Process||activation of phospholipase C activity (0007202)|
|12676795||Trk receptors: roles in neuronal signal transduction||Annu Rev Biochem||2003|
|10579907||Phospholipase C-gamma as a signal-transducing element||Exp Cell Res||1999|