Signalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation of MAPK found in NGF-treated cells.
|GO Biological Process||Ras protein signal transduction (0007265)|
|BioModels Database||BIOMD0000000175, BIOMD0000000019, BIOMD0000000424, BIOMD0000000255, BIOMD0000000399|
|11520933||Nerve growth factor signaling, neuroprotection, and neural repair||Annu Rev Neurosci||2001|