Reactome: A Curated Pathway Database

Signalling to RAS

Stable Identifier
R-HSA-167044
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Signalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation of MAPK found in NGF-treated cells.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events
Cross References