Reactome: A Curated Pathway Database

Signalling to RAS (R-HSA-167044)

Species Homo sapiens


Signalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation of MAPK found in NGF-treated cells.

Locations in the PathwayBrowser
Additional Information
GO Biological Process Ras protein signal transduction (0007265)
Cross References
Database Identifier
BioModels Database BIOMD0000000175, BIOMD0000000019, BIOMD0000000424, BIOMD0000000255, BIOMD0000000399
Literature References
pubMedId Title Journal Year
11520933 Nerve growth factor signaling, neuroprotection, and neural repair Annu Rev Neurosci 2001