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Hypophosphorylation of RNA Pol II CTD by FCP1P protein

Stable Identifier
Homo sapiens
Related Species
Human immunodeficiency virus 1
Locations in the PathwayBrowser

This HIV-1 event was inferred from the corresponding human RNA Pol II transcription event. FCP1 dephosphorylates RNAP II in ternary elongation complexes as well as in solution and, therefore, is thought to function in the recycling of RNAP II during the transcription cycle. Biochemical experiments suggest that human FCP1 targets CTDs that are phosphorylated at serine 2 (CTD-serine 2) and/or CTD-serine 5. It is also observed to stimulate elongation independent of its catalytic activity. Dephosphorylation of Ser2 - phosphorylated Pol II results in hypophosphorylated form that disengages capping enzymes (CE).

Literature References
Participant Of
This entity is regulated by:
Title Physical Entity Activity
phosphoprotein phosphatase activity of CTDP1 [nucleoplasm] CTDP1 [nucleoplasm] phosphoprotein phosphatase activity (0004721)
Inferred From
Name Identifier Synonyms