Reactome: A Curated Pathway Database

Phosphorylation (Ser5) of RNA pol II CTD

Stable Identifier
R-HSA-167098
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylation of serine 5 residue at the CTD of pol II largest subunit is an important step signaling the end of initiation and escape into processive elongation processes. Cdk7 protein subunit of TFIIH phosphorylates RNA Pol II CTD serine 5 residues on its heptad repeats (Buratowski 2009).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
kinase activity of TFIIH [nucleoplasm] TFIIH [nucleoplasm] kinase activity (0016301)
Inferred From
Disease
Diseases
Name Identifier Synonyms