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Phosphorylation (Ser5) of RNA pol II CTD

Stable Identifier
R-HSA-167098
Type
Reaction
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylation of serine 5 residue at the CTD of pol II largest subunit is an important step signaling the end of initiation and escape into processive elongation processes. Cdk7 protein subunit of TFIIH phosphorylates RNA Pol II CTD serine 5 residues on its heptad repeats (Buratowski 2009).

Literature References
PubMed ID Title Journal Year
19941815 Progression through the RNA polymerase II CTD cycle Mol. Cell 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
kinase activity of Pol II transcription complex containing extruded transcript to +30 [nucleoplasm]
Physical Entity
Activity
Inferred From
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection