Reactome: A Curated Pathway Database

Phosphorylation (Ser5) of RNA pol II CTD (R-HSA-167098) [Homo sapiens]


Phosphorylation of serine 5 residue at the CTD of pol II largest subunit is an important step signaling the end of initiation and escape into processive elongation processes. Cdk7 protein subunit of TFIIH phosphorylates RNA Pol II CTD serine 5 residues on its heptad repeats (Buratowski 2009).

Additional Information
Compartment nucleoplasm
Catalyst Activity
PhysicalEntity Activity Active Units
TFIIH kinase activity (0016301)
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 [HIV infection]
Literature References
pubMedId Title Journal Year
19941815 Progression through the RNA polymerase II CTD cycle Mol. Cell 2009